Gamma Hydroxybutyric Acid (GHB) Intoxication
نویسندگان
چکیده
منابع مشابه
Gamma hydroxybutyric acid (GHB) intoxication.
Gamma hydroxybutyric acid (GHB) is a naturally occurring analog of gamma-aminobutyric acid (GABA) that has been used in research and clinical medicine for many years. In the past decade it has become very popular as a dietary supplement and recreational drug. Acute overdose leads to profound alteration of mental status and variable amounts of respiratory depression. With proper management, most...
متن کاملGamma-hydroxybutyric acid (GHB) withdrawal: a case report.
GHB is an increasingly popular drug of abuse that can be associated in select cases with growing dependence and a severe withdrawal syndrome. While benzodiazepines are recommended for treatment of the withdrawal syndrome, some cases have been described as benzodiazepine-resistant. The authors describe treatment of such a case, which was unsuccessfully treated initially with benzodiazepines, the...
متن کاملGamma-hydroxybutyric acid (GHB) measurement by GC-MS in blood, urine and gastric contents, following an acute intoxication in Belgium.
Gamma-hydroxybutyrate (GHB, sodium oxybate) is a compound related to neuromodulator gamma-aminobutyric acid (GABA), emerging as a recreational drug of abuse and as a rape drug. GHB-related emergencies have dramatically increased in the 1990s, but a decrease is observed since 2000. We describe the case of an acute GHB intoxication in a 28-year-old male who fell unconscious after ingestion of a m...
متن کاملThe reactivity of gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL) in alcoholic solutions.
In this work the stability of GBL (gamma-butyrolactone) and GHB (gamma-hydroxybutyric acid) in alcoholic media was studied. Under acidic conditions the GBL will react with ethanol or methanol to give the corresponding ethyl and methyl esters of GHB. It can be seen that ester formation is dependent on the type of alcohol, the alcohol content of the solution, and the pH of the solution. Under the...
متن کاملStudy of Gamma-Hydroxybutyric Acid (GHB) Concentrations in Postmortem Blood and Urine
The GHB concentration in majority of the blood samples (95%) was ≤ 50 mg/L, while in 81% it ranged from 10-50 mg/L. In 95% of the urine samples, the GHB concentration ranged from 10-20 mg/L while 82% of the samples had a concentration of < 10 mg/L. In cases where GHB intoxication was identified, GHB concentrations ranged from 264 to >500 mg/L. The proposed published GHB concentration of 50 mg/L...
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ژورنال
عنوان ژورنال: Academic Emergency Medicine
سال: 2002
ISSN: 1069-6563
DOI: 10.1197/aemj.9.7.730